Pair Name	Curcumin, Doxorubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Up-regulation	Expression	VIM	hsa7431
	Down-regulation	Expression	CDH1	hsa999
	Up-regulation	Expression	CASP3	hsa836
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
	H22	Hepatocellular carcinoma	Mus musculus (Mouse)	CVCL_H613
In Vivo Model	BALB/c mice were subcutaneously implanted with H22 cells at a concentration of 1×10⁶ cells per mouse.Therapeutic drugs (DOX, 3 mg/kg; CUR, 0.75 mg/kg) were injected into the mice in the treated groups (saline, DC, DOX/Pep2, DOX/Pep1, DC/Pep2, DC/Pep1) via the tail vein every other day for 14 days starting on day 6. The tumor sizes and mouse body weights were measured every other day.
Result	Our findings provide a novel and simple approach to nhibit the growth and metastasis of hepatocellular carcinoma.